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I am not sure why you called Frieren and Apothecary Diaries isekais. The former is classical fantasy, while the latter is a historical fiction in the setting hevily inspired by late Ming dynasty China.
Isekai specifically means that the main character got transferred to another world, no reason to lump anything with fictional world as a setting with it.
But overall I am second on this list.
I will also add a relatively not so old series Yomigaeru Sora - realistic anime about everyday job of JP rescuers.
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