Cancer-killing pill that annihilates tumours hailed
as ‘holy grail’ breakthrough
"Scientists have developed a ‘holy grail’ molecule that kills
all solid cancer tumours, leaving healthy cells unaffected.
The team at the City of Hope, one of the largest cancer
research and treatment organisations in the US, made the
breakthrough against the proliferating cell nuclear antigen
(PCNA) protein.
In a mutated form PCNA is critical in DNA replication and
repair of all expanding tumours, but a molecule
developed by the team, AOH1996, targets and kills the
mutated PCNA.
Previously PCNA was thought too challenging to be a
target for therapy, but preclinical research shows AOH1996
seems to annihilate all solid tumours – without effects on
other body cells.
The team is continuing to investigate the mechanisms that
make this cancer-stopping pill work in animal models,
while a Phase 1 clinical trial test is also ongoing in humans.
However, it is not yet known if the drug will continue to be
taken in pill form once fully developed and approved for
use."
See:
https://metro.co.uk/2023/08/01/cance...ists-19228101/