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I don't think any U.S. American feels responsible for what Columbus did, he was an Italian sailor acting under Spain's command. Hell, Columbus didn't even visit any of the territories that would later become the U.S. If anything the recent popular criticism toward Columbus in the U.S (but mind you, not in any Latin American country) is due to the fact U.S. Americans do not believe they have anything to do with him, and it's mainly Italian-Americans that defend him.
If there's something U.S. Americans should feel guilty about is how they treated Native Americans in the course of the years after obtaining Independence (Originally England didn't even fight them and instead allied with some tribes), but of course that's not what they think about, it's the Italian sailor working for Spain the true villain.
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